Effect of topically applied ketotifen on allergic rhinitis in actively sensitized guinea-pigs.
نویسندگان
چکیده
منابع مشابه
Early and late allergic phase related cough response in sensitized guinea pigs with experimental allergic rhinitis.
Cough is a common and important symptom of asthma and allergic rhinitis. Previous experimental evidence has shown enhanced cough sensitivity during early phase of experimental allergic rhinitis in guinea pigs. We hypothesized that airway inflammation during the late phase response after repeated nasal antigen challenge may affect the afferent sensory nerve endings in the larynx and tracheobronc...
متن کاملEffect of KW-4679, an orally active anti-allergic drug, on antigen-induced airway hyperresponsiveness in actively sensitized guinea pigs.
We investigated the effect of KW-4679 ((Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2- acetic acid monohydrochloride), an orally active anti-allergic drug, on antigen-induced airway hyperresponsiveness using two different indicators, pulmonary resistance (RL) and dynamic lung compliance (Cdyn), in actively sensitized guinea pigs. Oral administration of KW-4679 (0.1 and 1...
متن کاملFirst experiences with cough sensitivity in model of allergic rhinitis induced in HDM-sensitized guinea pigs
Background Nowadays, the vast majority of research focusing on cough in sensitive and/or hyperreactive airways is done on an animal model of guinea pigs intraperitoneally sensitized by ovalbumin. There are no objections to model animal – the neurophysiology and neuropharmacology of their n. X are closest to humans. However, the choice of ovalbumin as model antigen together with the route of adm...
متن کاملEvaluation of the Effect of Onosma Bracteatum Wall (Boraginaceae) On Bronchial Hyperreactivity in Sensitized Guinea Pigs
Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Onosma bracteatum ( O. bracteatum ) is know...
متن کاملEffect of local nasal immunotherapy on nasal blockage in pollen-induced allergic rhinitis of Guinea pigs.
BACKGROUND As a non-injection route for immunotherapy, local nasal immunotherapy has been examined in allergic rhinitis patients. However, it is unclear how the immunotherapy affects sneezing, biphasic nasal blockage and nasal hyperresponsiveness. Thus, we evaluated the therapeutic effects of nasal immunotherapy on the symptoms of guinea pig allergic rhinitis. Additionally, we also evaluated wh...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)37032-5